"Best possible hand in most poker variants" NYT crossword answer is:ROYALFLUSH (10 letters length)
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The best possible hand in most poker variants is a Royal Flush, which consists of a ten, jack, queen, king, and ace of the same suit. This is the highest possible hand in poker and is incredibly rare, making it a highly sought-after combination. It is also the most difficult hand to achieve, as it requires a player to have all five cards of the same suit in their hand.